Best Supplements For Men Over 40 (2023 Guide)
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Best Supplements For Men Over 40 (2023 Guide)

As we understand more about health in recent years, we’re also learning more about the health needs of maturing men. In the same breadth this same category of men are starting to take a more hands-on approach to their bodies- and rightly so. Research has uncovered a disturbing trend- men have increased health risks due to biological and social factors. As the threat of disease and chronic illness rises, we have to act preemptively through disease prevention and physical fitness.

One of the best tools available to us to prevent the breakdown of the body is nutrition. Nature has not only provided food that’s pleasurable to eat, but within it every vitamin, mineral, and macronutrient necessary to keep the body healthy and balanced. While I’d always recommend well-balanced, nutrient-dense diet first and foremost, sometimes certain essential nutrients get left out- especially as men age. In order to get what the body needs to age well and without disease, supplementation is also a viable option. In this article we’ll explore the best supplements for men over 40 to maintain or attain robust health for decades to come.

Essential Nutrients For Men Over 40

When it comes to men’s overall health, ensuring the best quality of life takes a lot of understanding and strategy. The body is a sophisticated machine that needs both upkeep through physical fitness and maintenance through nutrition.

The first step is identifying which vitamins and minerals the body needs and why. Keep in mind that the list below isn’t EVERY nutrient your individual body needs. Your healthcare provider can give you a much clearer picture of what you need specifically, however the nutrients below cover a large portion of what men over 40 need in a balanced diet.

Vitamin D

benefits for men:

– inflammation

– bone health

– immune health

Vitamin D is one of the cornerstones of men’s health for numerous reasons. To start Vitamin D is one of the key vitamins for bone health. It actively works to absorb calcium from various sources all while balancing the body’s serum calcium and phosphate levels. This in turn allows for normal bone-mineralization. As men age, we become more susceptible to osteoporosis, a condition that weakens the bones- often leading to fractures. Without vitamin D those odds are even greater, leaving the bones thin, brittle and misshapen.

Skeletal muscle is also influenced by the presence of vitamin D. Vitamin D deficiency has been associated with decreased muscle size and strength(1). This weakness in the muscles has led to increased falls in the elderly and bone fractures in large part due to the lack of d vitamins.

The necessity of vitamin D doesn’t stop with skeletal muscle or bone. Research published in the American Journal of Clinical Nutrition has shown that a higher intake of vitamin D is linked to reduced risks of cardiovascular diseases in men. It is also a powerful agent of immune support. As a result, men over 40 can see optimal immune function and overall health by incorporating this micro-nutrient.

A growing body of studies have concluded that vitamin D supplementation has the potential to protect against certain types of cancer, including prostate cancer. For any man nearing or beyond 40, the risk of developing prostate cancer is a real concern- which means taking preventative measures with Vitamin D is an important step towards a healthy lifestyle.

Vitamin B12

benefits for men:

– brain health

– depression prevention

– enhanced energy

– heart disease

B12 is another key nutrient for men over 40 specifically for its part in sustaining high energy levels, maintaining brain health, and protecting against cognitive decline.

B12, also known as cobalamin, is a water soluble vitamin that’s absorbed in the stomach and transported through the blood. B vitamins, including B12, help support energy production in the body. Research has found that deficiencies in B12 can lead to reduced energy levels and exercise tolerance. It has also been found to lead fatigue and shortness of breadth. As men age, their energy levels may naturally decline, making B12 supplementation or adequate intake through diet crucial for maintaining optimal energy levels.

Brain function is also a huge benefit of B12. I don’t have to tell you how serious mental decline is in older adults, but fortunately B12 offers support for cognitive functioning. Its also been known to improve mood, as well as increase focus and concentration.

Omega 3 Fatty Acids

benefits for men:

– heart health

– eye health

– inflammation

Omega-3 fatty acids are essential for men over 40 due to their numerous health benefits, particularly in supporting heart health and reducing the risk of various chronic conditions. Here’s why omega-3 is essential for men over 40:

Omega-3’s are considered the “healthy fats” that offer lots of support for a healthy heart. Heart disease is currently the leading cause of death in the country, especially among aging men. To combat this, omega-3 fats keep the heart beating healthy and strong with lower blood pressure and heart rate, as well as improved vaso-dialation.

On top of this omega-3 affects heart health by bringing down triglyceride levels, circulating HDL (good) cholesterol, and actively preventing the formation of harmful blood clots. These effects contribute to a reduced risk of cardiovascular disease, which is especially important for men over 40, as the risk of heart disease increases with age.

The brain is also directly affected by Omega-3s, impacting cells’ membrane fluidity, their function, as well as neurotransmitter release. If cells have low levels of omega-3 in their membranes it can disrupt nerve transmitters and evolve into cognitive decline and certain mood disorders.

In addition omega-3 has anti-inflammatory properties, improve eye health, and maintain the endocrine system- the body’s hormone headquarter.


benefits for men:

– immune health

– healthy cell growth

– sexual health

– testosterone levels

Zinc is an essential mineral for immune health and fighting diseases in the body, a pivotal role among older adults. It works by putting the body’s natural killer cells, T-cells on high alert. These T-cells then protect the body from any ongoing or potential infections. Findings indicate that older adults who take zinc supplements may experience an improved influenza vaccination response and a reduced risk of pneumonia.

This mineral is involved with other age-related illnesses including infection, and age-related macular degeneration (AMD). A study found that daily antioxidant supplements (including zinc) helped to minimize vision loss and drastically reduce the risk of advanced AMD.

On top of fending off diseases, zinc is also pivotal for recovering from wounds- a process that takes longer as we age. It also prevents the onset of osteoporosis as an active participant in bone formation. Zinc also ensures the function of taste and smell, maintains proper hormonal balance and sexual health in men, and helps with varying skin conditions including acne vulgaris, hidradenitis suppurativa, atopic dermatitis, and diaper dermatitis.

Coenzyme Q10

– heart health

– reduced depression

– antioxidant effects

– physical performance

benefits for men:

Coenzyme Q10 is essentially an antioxidant that converts food into energy. It has been shown to improve heart health, reduce the risk of heart-related events, and help manage conditions such as heart failure, high blood pressure, and angina.

It works to eradicate harmful free radicals and guard cells from oxidative damage. As men age, age related diseases and conditions expedite oxidative stress in the body, so having substances in the body to combat its affects is essential. Coenzyme Q10 may also help prevent cognitive decline, support cholesterol levels, and improve the physical performance of individuals with muscular dystrophy.


– prevents muscle loss

– bone health

– weight loss

benefits for men:

Protein is an essential macronutrient and one of the best supplements for men over 40 for several reasons. As men get older, there is a natural decrease in muscle mass and strength called sarcopenia. However its affects can be slowed with an abundance of protein in the diet. Consuming 1-1.2 g of protein per kilogram of bodyweight can help preserve muscle mass and support healthy aging.

Protein is also important for maintaining strong and healthy bones. With the risk of osteoporosis increasing as men age, consuming an adequate amount of protein can fortify the bones and protect the the skeletal system against falls and fractures.

Another important point about protein is its filling effect. It’s more satiating than carbohydrates or fats, meaning it can help you feel fuller for longer and reduce overall calorie intake. This can be particularly beneficial for men over 40 who may be more prone to weight gain and have a harder time losing weight.

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7 Best Supplements For Men Over 40

Nature Made Zinc 30 mg Tablets

best for men’s immune health, sexual health, testosterone

Nature Made is already known for producing some of the best supplements for men over 40 on the market, and their zinc tablets are a part of that reputation. One of these 30 mg tablets is your daily dose of antioxidants and immune support, fortifying your body against viruses and illnesses.

Nature Made’s zinc comes with 100 servings for long lasting supply at an excellent price. This product keeps things simple and clean- it’s sourced from quality ingredients, gluten free, with no added color, artificial flavors or preservatives.

Consistent with Nature Made’s standard of quality, these tablets have been tested and verified by the United States Pharmacopeia. This ensures that you get the best quality product along with the best immune system support year- round.


With the world dealing with the residual damage done by COVID, customers nation-wide are generally pleased with this product’s effectiveness. It’s appearently great for warding off colds and viruses, and is also very easy to swallow. These supplements are a great way for men over 40 to boost their immune health and with 100 servings per bottle you can be sure Nature Made will last you for the long haul.

Nature Made Vitamin D3 125 mcg

best for bone health, immune support, and inflammation

Nature Made is back on our list with its vitamin D3 tablets. About 95% of adults fail to get enough vitamin d through dieting alone- depriving most of us from this essential vitamin. Fortunately Nature Made has a wide variety of D vitamins to choose from, whether a dosage as low as 25 mcg or as high as 5,000 mcg. With these dosages to choose from you’ll easily fill any nutrient gaps in your nutrition and benefit from strengthened bones, teeth, and muscles, improved immune health, a better overall mood.


For those who’ve taken Nature Made D3 for a decent length of time praise the supplement for it’s value and effectiveness. The consensus is that these D3 pills are very easy to swallow and because of the lack of artificial color or flavoring they don’t leave any unpleasant aftertastes. Despite there high dosage customers haven’t expressed any side- effects and tout that its helped their overall health in numerous ways.

BioTrust Ageless Multi-Collagen Protein Powder

best for skin, bone, and hair support, muscle growth and bone health

Protein powder is probably the most pushed supplement out there, but rest assured this is no ordinary protein. This is one of the best supplements for men over 40 because it is COLLAGEN powder. Believe it or not collagen is the most abundant (and perhaps the most important) protein in the human body. Beside water, collagen is the most present substance in the body, making up 30% of the protein in the body!

It is the main structural protein of the joints, bones, cartilage, hair, intestinal wall, and much more. In a way it is the cement that holds the building blocks of the body together. As we begin to age, our collagen production naturally slows down and the cellular structures weaken.

Unlike most common protein sources, this collagen powder is packed with glycine, proline, and hydroxyproline. These three amino acids account for 40 – 50% of the amino acids in collagen protein, which is 10 – 20 times higher than other common protein sources.

BioTRUST’s collagen protein powder provides 5 different beneficial collagens to support healthy hair, skin, and nails. It also offers joint, gut and bone health all while improving athletic performance and recovery for the active lifestyle.


This might be one of the best supplements for men on this list for numerous reasons. To start the flavors are highly rated and the powder itself is smooth and dissolves well into coffee or protein shakes. On top of stimulating protein synthesis and muscle growth BioTRUST’s powder has also provided users wonderful support for soft nails, dry, itchy skin, achy joints, etc. For some it has helped in re-growing hair post-cancer and provided others with noticeably softer, smoother skin.

If you’re looking for a great tasting product that offers noticeable, lasting benefits for your skin, hair, nails, joints, and muscles as you get older- BioTRUST’s collagen protein is an excellent investment.

BioTRUST Ageless Body- Healthy Aging Support Formula

best for energy, testosterone, and cellular aging

BioTRUST’s Healthy aging formula is a cocktail of nutrients that are beneficial for maturing men. For this fact alone makes it is one of the best supplements for men over 40. To start Ageless Body promotes healthy cellular aging and energy levels by supporting the mitochondria, the power-plant of the cell.

The product’s tumeric extract ensures greater absorption and ultimately greater effectiveness of the multiple other ingredients. It contains ashwagandha extract for stress management, increased energy, and potentially higher testosterone levels.

Ageless body also contains numerous antioxidants such as gluthione, CoQ10, and vitamin C- all powerful agents for protecting the body against infection, joint health, and detoxification.


BioTRUST has honed in on its craft of creating quality, anti-aging products with Ageless Body. This product like many others of the brand comes highly rated, mainly for noticeable cellular repair and powerful anti-aging properties. Many users mention how they “feel” the difference in their joints and notice the difference in their skin almost immediately.

Jarrows Formulas Maximum Strength B-12 1000 mcg

best for brain health, heart disease, and energy

Jarrow Formulas Maximum B12 tablets are a simple way for those that need vitamin B, vegans, vegetarians, and older men for brain health and continuous energy. Methyl B-12 is the active version of the vitamin and as it turns out is more readily absorbed and held by the body. With methyl B-12 you’ll get more effectiveness with increased cellular energy production and improved brain health and sleep. Jarrows’ keeps things clean and quality with no GMOs, wheat, soy, dairy, shellfish, or nuts.

Every lemon-flavored cheweble tablet packs 1000 mcg of Methyl B-12, a healthy dosage designed to protect the brain cells, nerve tissue and assistance to neurotransmitters. Only one pill a day is necessary and with 100 servings you can expect neural and energy support for months on end.


All in all Jarrow’s B12 supplement is an excellent source of B12. Hundreds have praised this product for its great taste and easy consumption. Just as many have also mentioned the increased energy and mental clarity this supplement has provided, some noticing the difference as soon as 1 to 2 weeks.

Nature Made Omega-3 1400 mcg

best for heart health, eye health, and inflammation

Nature Made Omega-3s is a fish oil supplement designed to help improve heart health, the brain, and eyes. This product is simply what is advertised, it’s been purified to remove mercury and contains no added color, milk, shellfish, and is gluten free.

It comes in a softgel capsule that makes it easier to swallow and a formula specifically for a burp-less experience with a less fishy odor and aftertaste.


This quality soft-gel is an excellent supplement for men over 40 to replenish the body’s need for polyunsaturated fat. According to many users, this product is smaller than other fish oil pills, very easy to swallow, and free from any fishy after-tastes associated with soft-gel fish oils.

With its simple, quality ingredients, you can rest assured that these pills are working on your behalf to improve your heart, brain, and eyes!

BioTRUST Eternal Reds Superfood Powder

best for antioxidants, nitric oxide levels, energy, and blood flow

Eternal Reds is another BioTRUST favorite that combines the power of 10 polyphenol packed superfoods working to provide youthful vitality, healthy energy levels, and anti-aging.

Eternal Reds literally has all the nutrients the body needs for robust health and longevity. This superfood powder contains powerful phytochemicals and polyphenols from ingredients like beet root and pomegranate extract that improve blood flow, nitric oxide levels, and physical energy.

Eternal Reds also has a delicious blend of 9 antioxidant fruits and berries, such as Grape, Cranberry, Blueberry, Pomegranate, Apple, Blackberry, Bilberry, Raspberry, and Strawberry– justifying both its positive health benefits and great flavor.

On top of all that, Eternal Reds provides you with a performance blend of three additional circulation powerhouse nutrients, including betaine, taurine, and vitamin C.


The overwhelming consensus for this supplement is very positive. To start many people are enthralled with Eternal Red’s taste, some wondering how something that tastes so good could be healthy! The thoughtful balance of red fruits and vegetables creates a flavor profile that isn’t too sweet or too tart.

Fortunately Eternal Red also works as well as it tastes. Some users have attested to how its helped lower their blood pressure and revitalize their energy levels, in some cases as soon as 3 weeks. This doesn’t

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